| 摘要 |
Disclosed are a controlled release preparation with improved performance and a method for preparing the controlled release preparation. The controlled release preparation comprises: a core containing drugs and a controlled release coating coated on the core. The controlled release coating contains a plasticizer, a polymer that is insoluble in water and gastrointestinal digestive juice, and particles of a porogen which are embedded in the polymer and coated by a polymer coating soluble in gastric juice and/or intestinal juice but insoluble in water. The reproducibility of drug release of the controlled release preparation is improved, the release time lag is reduced, and the bioavailability is improved. Therefore, targeted and controlled release of drugs in gastrointestinal track is achieved.
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