| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a flowable composition for use as a controlled release implant including a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid, a biocompatible polar aprotic solvent which is miscible to dispersible in aqueous medium or body fluid and leuprolide acetate, an implant or a kit comprising such composition, and to provide a method for forming the flowable composition. <P>SOLUTION: The invention relates to: a biodegradable implant formed in situ, in a patient; a method of forming a biodegradable implant in situ, in a living patient which includes a step of injecting a flowable composition within the body of the patient and a step of allowing the biocompatible polar aprotic solvent to dissipate to produce a solid biodegradable implant; and a method of treating cancer in a patient by administering to the patient in need of such treatment an effective amount of a flowable composition or a method of reducing LHRH levels in a patient. <P>COPYRIGHT: (C)2012,JPO&INPIT |
