| 摘要 |
Disclosed is a use of a polymer reinforcing agent in production or storage of a controlled-release preparation and especially a controlled-release preparation of zero-order release. A performance-improved, controlled-release preparation and especially controlled-release preparation of zero-order release are further disclosed. The controlled-release preparation comprises a core containing a biologically active substance, and a controlled-release polymer coat externally applied to the core containing both numerous air-filled agent-releasing micro-pores and a polymer reinforcing agent, wherein the contact angle between the polymer and the polymer reinforcing agent is less than 90°, and the agent-releasing micro-pores are obtained by sublimating a sublimable substance and/or degrading a substance that is capable of being degraded into a harmless gas. The controlled-release coat of the controlled-release preparation has good mechanical performance, and has high storage stability with respect to drug releasing. |
