发明名称 |
Compositions and methods for therapy and diagnosis of cancer |
摘要 |
<p>The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer.</p> |
申请公布号 |
EP2357233(A3) |
申请公布日期 |
2012.01.18 |
申请号 |
EP20110002009 |
申请日期 |
2006.12.07 |
申请人 |
JOHANNES GUTENBERG-UNIVERSITAET MAINZ;GANYMED PHARMACEUTICALS AG |
发明人 |
SAHIN, UGUR;TUERECI, OEZLEM;KOSLOWSKI, MICHAEL |
分类号 |
C12N15/113;A61K31/713 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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