发明名称 |
CELL-SPECIFICALLY EFFECTIVE MOLECULES ON THE BASIS OF SIRNA AND APPLICATION KITS FOR THE PRODUCTION THEREOF AND USE THEREOF |
摘要 |
<p>A biologically inactivated cell-specifically effective molecule for biologically inactive transfection into a target cell to inhibit expression of genes in the target cell after biological activation of the molecule, by bonding to mRNA and with the formation of a RISC complex, the biologically inactivated cell-specifically effective molecule comprising siRNA coupled with at least one peptide via a linker which remains at the siRNA after biological activation of the molecule, the linker comprising an amino Cn linker wherein n is an integer of 1-6. Kits include the molecule or the constituents thereof and transfection reagents in ampoules and injection equipment for injecting mixtures of the ampoule contents into a medium containing a target cell.</p> |
申请公布号 |
EP2406375(A1) |
申请公布日期 |
2012.01.18 |
申请号 |
EP20100718039 |
申请日期 |
2010.03.12 |
申请人 |
FRIEDRICH-SCHILLER-UNIVERSITAET JENA |
发明人 |
IMHOF, DIANA;KOEHN, SANDRA;POEHLMANN, TOBIAS |
分类号 |
C12N15/11;C12N15/113 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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