Synthetic intermediate in the production of a sulfonamide derivative having PGD2 receptor antagonistic activity

摘要

The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (V):
wherein the ring D is a benzene ring etc.; R 1 is hydroxyalkyl etc.; R 2 is independently a hydrogen atoms etc.; R 8 is a halogen atom etc.; L 3 is independently a single bond etc.; R 7 is independently a hydrogen atom etc.; and p is 1, 2, 3 or 4; provided that the substituting position of the piperidino group and L 3 each other is not an ortho-position in the ring D when the ring D is a benzene ring and -L 3 - is -(O-alkylene)-;
a pharmaceutically acceptable salt or hydrate thereof.