发明名称 |
PROPHYLACTIC OR THERAPEUTIC AGENT FOR OPTIC NERVE DISORDERS COMPRISING 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT |
摘要 |
<p>Disclosed is a compound useful as a preventive or therapeutic agent for optic nerve disorders, an inhibitor of retinal ganglion cell death or an agent for restoring the expression level of a neurofilament light chain, particularly a compound capable of exhibiting the abovementioned pharmacological activities when administered orally. A 4,6-dichloro-1H-indole-2-carboxylic acid derivative or a salt thereof can significantly inhibit the decrease in the number of cells in a retinal ganglion cell layer of an NMDA-induced rat retinal disorder model when administered to the model orally, and can also restore the decrease in the expression level of a neurofilament light chain in a retina of the model when administered to the model intravitreally (intraocular local administration). Therefore, the compound or a salt thereof is useful as a preventive or therapeutic agent for optic nerve disorders, an inhibitor of retinal ganglion cell death or an agent for restoring the expression level of a neurofilament light chain.</p> |
申请公布号 |
EP2407454(A1) |
申请公布日期 |
2012.01.18 |
申请号 |
EP20100750846 |
申请日期 |
2010.03.10 |
申请人 |
SANTEN PHARMACEUTICAL CO., LTD |
发明人 |
SASAOKA, MASAAKI;UMEMOTO, TOMOKO;SEIKE, HISAYUKI;KAGEYAMA, MASAAKI |
分类号 |
C07D209/42;A61K31/405;A61P27/02;C07D403/06 |
主分类号 |
C07D209/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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