| 摘要 |
The present invention relates to improved methods for the production of viral particles, viral vectors and recombinant proteins. In particular, the invention relates to improved methods for the production of recombinant polyomavirus vector particles and polyoma vector production cell lines. More in particular, the invention relates to methods for the production of simian polyoma viral vector particles such as simian virus 40 (SV40) viral vector particles. The invention also relates to compositions comprising viral vectors and uses thereof and viral vector particles to treat genetic disorders, transplant rejection, autoimmune diseases, infectious diseases, allergies or cancer. The invention also relates to methods for the production of recombinant proteins in mammalian cells and methods to enhance the production of recombinant proteins in mammalian cells. |
