发明名称 |
Skin substitutes, preparation methods and uses thereof |
摘要 |
Provided herein are skin substitutes suitable for use in a living subject for purpose of repairing damaged tissues, methods of producing the skin substitutes and their uses. A biocomposite membrane comprising poly(ε-caprolactone) (PCL) and at least one material selected from collagen and gelatin is provided. In one embodiment, the biocomposite is a 2-component membrane of PCL and gelatin. In another embodiment, the biocomposite is a 3-component membrane of PCL, collagen and gelatin. The bio-composite membrane may be used directly in vivo as a wound dressing, or as a support for cell growth on each side of the membrane to produce an in vitro cultivated artificial skin for future in vivo and/or in vitro applications.
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申请公布号 |
US8097274(B2) |
申请公布日期 |
2012.01.17 |
申请号 |
US20090447434 |
申请日期 |
2009.07.23 |
申请人 |
COOMBES ALLAN GERALD ARTHUR;ADAMS ERIC FRANK;DAI NIANN-TZYY;LIU TSUNG-HSUN;YEH MING-KUNG;NATIONAL DEFENSE MEDICAL CENTER |
发明人 |
COOMBES ALLAN GERALD ARTHUR;ADAMS ERIC FRANK;DAI NIANN-TZYY;LIU TSUNG-HSUN;YEH MING-KUNG |
分类号 |
A61K9/70;A61F2/00;A61F2/02;A61F2/10;A61K31/04;A61K31/12;A61K31/13;A61K31/74;A61K31/785;A61K38/00;A61K45/00;A61K47/30;A61L15/00;A61P17/02;C08J9/00;C12N5/00;C12N5/02;C12N5/07;C12N5/071 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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