发明名称 |
Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
摘要 |
The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels. |
申请公布号 |
US8097254(B2) |
申请公布日期 |
2012.01.17 |
申请号 |
US20040821930 |
申请日期 |
2004.04.12 |
申请人 |
NERI DARIO;TARLI LORENZO;VITI FRANCESCA;BIRCHLER MANFRED;EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH |
发明人 |
NERI DARIO;TARLI LORENZO;VITI FRANCESCA;BIRCHLER MANFRED |
分类号 |
A61K39/00;A61K51/00;A61K38/39;A61K39/395;A61K51/10;A61P27/02;A61P35/00;A61P43/00;C07C63/04;C07K14/515;C07K16/18 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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