发明名称 |
PROCESS FOR DYNAMIC KINETIC RESOLUTION (DKR) OF RACEMIC COMPOUNDS IN (HYDRO) FLUOROCARBON SOLVENTS |
摘要 |
A process for preparing a third compound stereo-selectively which process comprises reacting a substrate comprising a first enantiomeric compound with a racemisation catalyst to give a second enantiomeric compound, and concurrently reacting the second enantiomeric compound in the presence of a biological catalyst to give the third compound, wherein the process is performed in a solvent comprising at least one (hydro) fluorocarbon. The biological catalyst is preferably an enzyme. The substrate preferably comprises a racemate of the first and second enantiomeric compounds. The second enantiomeric compound may be reacted with a reagent, such as acyl donor, to form the third compound in the presence of the biological catalyst.
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申请公布号 |
CA2644268(C) |
申请公布日期 |
2012.01.17 |
申请号 |
CA20072644268 |
申请日期 |
2007.04.19 |
申请人 |
INEOS FLUOR HOLDINGS LIMITED |
发明人 |
MICKLEFIELD, JASON;BALL, ANTHONY JOHN;CORR, STUART |
分类号 |
C12P41/00;C12P7/22;C12P7/62 |
主分类号 |
C12P41/00 |
代理机构 |
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主权项 |
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地址 |
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