发明名称 |
HEMMER VON SERIN-PROTEASE, INSBESONDERE VON HEPATITIS-C-VIRUS-NS3-NS4A-PROTEASE, MIT EINEM KONDENSIERTEN RINGSYSTEM |
摘要 |
The present invention relates to peptidomimetic compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. |
申请公布号 |
AT539744(T) |
申请公布日期 |
2012.01.15 |
申请号 |
AT20020782236T |
申请日期 |
2002.10.24 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;PERNIE, ROBERT B.;PITLIK, JANOS;VAN DRIE, JOHN H. |
发明人 |
PERNI, ROBERT;PITLIK, JANOS;VAN DRIE, JOHN;FARMER, LUC |
分类号 |
A61K31/403;C12N9/99;A61K31/13;A61K31/497;A61K31/7052;A61K38/00;A61K38/21;A61K45/00;A61P31/12;A61P31/14;A61P43/00;C07D403/12;C07K5/023;C07K5/06;C07K5/08;C07K5/083;C07K5/10;C07K5/103;C07K7/02;C07K7/06 |
主分类号 |
A61K31/403 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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