| 摘要 |
<p>Disclosed are dendritic cell-specific antibodies to which an engineered Nef antigen is attached to form an antibody-antigen complex, wherein the Nef antigen comprises one or more codon usage optimizations that increase antibody-antigen complex secretion. The antibodies are used in methods for increasing the effectiveness of antigen presentation of an antigen presenting cell (APC) by contacting the APC with an antibody under conditions which result in the antigen-antibody complex being processed and presented for T-cell recognition. The antibodies are also used in a vaccine to elicit an HIV-specific T-cell immune response.</p> |
