NOVEL COMPOUNDS 951: A BIPHENYLOXYPROPANOIC ACID AS CRTH2 MODULATOR AND INTERMEDIATES

摘要

Disclosed is a compound of formula (I): as a mixture of (2S)-2-({ 3'-chloro-4'-[(2,2-dimethylpyrrolidin-1-yl)carbonyl]-5-fluorobiphenyl-2-yl} oxy)propanoic acid and (2R)-2-({ 3'-chloro-4'-[(2,2-dimethylpyrrolidin-1-yl)carbonyl]-5-fluorobiphenyl-2-yl} oxy)propanoic acid, or solvates thereof or pharmaceutically acceptable salts thereof or solvates of pharmaceutically acceptable salts. Also disclosed is a process for preparing a compound of formula (I) a pharmaceutical product comprising a compound of formula (I) and the use of a compound of formula (I) for the manufacture of a medicament for treating a disease mediated by prostaglandin D2.