| 摘要 |
Disclosed is a compound which is represented by general formula (I) and has an inhibitory effect on ADAM17, a salt thereof, or a solvate thereof. In formula (I), X represents a phenylene group, Y represents a hydrogen atom, -(CH2)mR1, or the like, R1 represents -NR5COR2, -NR5SO2R2, or -NR3R4, R2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group, R3 and R4 each represent a C1-C6 alkyl group or the like, R5 represents a hydrogen atom, a C1-C6 alkyl group, or the like, m represents an integer of 0 to 4, and Z represents a hydrogen atom or a C1-C6 alkyl group.
|
