| 发明名称 |
5HT2C RECEPTOR MODULATORS |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide selective 5HT<SB POS="POST">2C</SB>agonists which safely decrease food intake and body weight, wherein a 5HT<SB POS="POST">2C</SB>receptor is a validated and well-accepted receptor target for the treatment of obesity and psychiatric disorders. <P>SOLUTION: The present invention relates to a compound represented by Formula (I) or a pharmaceutically acceptable salt, solvate or hydrate thereof. In the Formula (I), R<SB POS="POST">1</SB>is H or C<SB POS="POST">1-8</SB>alkyl; R<SB POS="POST">2</SB>is C<SB POS="POST">1-8</SB>alkyl or the like; R<SB POS="POST">2a</SB>is H; or R<SB POS="POST">2</SB>and R<SB POS="POST">2a</SB>together form -CH<SB POS="POST">2</SB>-CH<SB POS="POST">2</SB>-; R<SB POS="POST">3</SB>and R<SB POS="POST">4</SB>are each independently H or the like; or R<SB POS="POST">3</SB>and R<SB POS="POST">4</SB>together with the atoms to which they are attached can form a 5- or 6-memberd heterocyclic ring having one O atom; each R<SB POS="POST">5</SB>is independently C<SB POS="POST">1-8</SB>alkyl or the like; and R<SB POS="POST">6</SB>is H or C<SB POS="POST">1-8</SB>alkyl. <P>COPYRIGHT: (C)2012,JPO&INPIT |
| 申请公布号 |
JP2012006970(A) |
申请公布日期 |
2012.01.12 |
| 申请号 |
JP20110201117 |
申请日期 |
2011.09.14 |
| 申请人 |
ARENA PHARMACEUTICALS INC |
发明人 |
SMITH BRIAN;SMITH GEOFFREY |
| 分类号 |
C07D223/14;C07D223/16;A61K31/55;A61P1/00;A61P3/04;A61P5/24;A61P9/00;A61P11/00;A61P13/02;A61P15/00;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P43/00;C07D223/32;C07D403/04;C07D409/04;C07D487/00;C07D491/00;C07D491/04;C07D491/048;C07D513/00 |
主分类号 |
C07D223/14 |
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