发明名称 |
VIRION-LIKE DELIVERY PARTICLES FOR SELF-REPLICATING RNA MOLECULES |
摘要 |
<p>Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non- virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.</p> |
申请公布号 |
CA2804494(A1) |
申请公布日期 |
2012.01.12 |
申请号 |
CA20112804494 |
申请日期 |
2011.07.06 |
申请人 |
NOVARTIS AG |
发明人 |
GEALL, ANDREW;MANDL, CHRISTIAN;O'HAGAN, DEREK;SINGH, MANMOHAN |
分类号 |
A61K39/155;A61K39/245;C12N15/86;C12N15/88 |
主分类号 |
A61K39/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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