发明名称 HUMAN MONOCLONAL ANTIBODY AGAINST CD20
摘要 <P>PROBLEM TO BE SOLVED: To provide human monoclonal antibodies which bind to and inhibit human B-lymphocyte surface antigen CD20, and methods for using the antibodies. <P>SOLUTION: The human anti-CD20 monoclonal antibodies are produced by a transfectoma or in a non-human transgenic animal, producible of multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also there are provided: pharmaceutical compositions comprising transgenic animals and hybridomas, which produce the antibodies, and the antibodies; and therapeutic and diagnostic methods by using the antibodies. <P>COPYRIGHT: (C)2012,JPO&INPIT
申请公布号 JP2012005485(A) 申请公布日期 2012.01.12
申请号 JP20110148994 申请日期 2011.07.05
申请人 GENMAB AS 发明人 TEELING JESSICA;RUULS SIGRID;GLENNIE MARTIN;VAN DE WINKEL JAN G J;PARREN PAUL;PETERSEN JORGEN;BAADSGAARD OLE D M SC;HUANG HAICHUN
分类号 C12N15/09;A61K35/74;A61K35/76;A61K39/395;A61K45/00;A61K48/00;A61P1/04;A61P3/10;A61P7/04;A61P7/06;A61P9/08;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P21/04;A61P25/00;A61P29/00;A61P31/18;A61P31/22;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K16/28;C07K16/42;C12N5/10;C12N5/22;C12N5/24;C12P21/08;G01N33/53 主分类号 C12N15/09
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