GLP-1 Exendin-4 peptide analogs and uses thereof

摘要

The invention relates to novel polypeptide analogues of GLP- I and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. 5 Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP- 1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues 10 thereof for neuroprotective and neurotrophic effects.