摘要 |
Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents; to predict a time course of disease or a probability of a significant event in the disease of a cancer patient; to stratify patient populations; and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling. |
申请人 |
INFINITY PHARMACEUTICALS, INC.;CAMPBELL, VERONICA, TRAVAGLIONE;FAIA, KERRIE, L.;KUTOK, JEFFERY, L.;MACDOUGALL, JOHN, R.;MCGOVERN, KAREN, J.;PAEZ, JUAN, GUILLERMO;PELUSO, MARISA, OSSWALT;SKLIRIS, GEORGIOS;WHITE, KERRY |
发明人 |
CAMPBELL, VERONICA, TRAVAGLIONE;FAIA, KERRIE, L.;KUTOK, JEFFERY, L.;MACDOUGALL, JOHN, R.;MCGOVERN, KAREN, J.;PAEZ, JUAN, GUILLERMO;PELUSO, MARISA, OSSWALT;SKLIRIS, GEORGIOS;WHITE, KERRY |