DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS

摘要

Disclosed are compounds having the formula 1-3 e.g. 5-(3,5-dicyano-1,4-dihydro-2,6-dimethyl-4-pyridinyl)-3-[(2-hydroxyethyl)-amino)-1H-indazole-1-carboxylic acid, 1,1-dimethylethyl ester and 1 ,4-dihydro-2,6-dimethyl-4-[3-[(3-pyridinylmethyl)amino]-1H-indazol-5-yI1-3,5-pyridinedicarbonitrile wherein A, B, D, X, Y, and Z, R3, R4, R5, R6 and R10 are defined in the specification or their pharmaceutically acceptable derivatives or salts for the treatment of cancer.