The invention provides methods of making and using compounds of the formula shown, which are inhibitors of human plasmin and plasma kallikrein. (Formula I) The compounds are useful for the prevention of blood loss, and as components of fibrin adhesives.
申请公布号
WO2012004678(A2)
申请公布日期
2012.01.12
申请号
WO2011IB02279
申请日期
2011.07.05
申请人
THE MEDICINES COMPANY (LEIPZIG) GMBH;STEINMETZER, TORSTEN;SAUPE, SEBASTIAN, MARTIN