METHOD FOR REGULATING SURVIVAL AND MEMORY OF T HELPER 1 CELLS

摘要

The present invention provides a method of inhibiting survival of T helper 1 (Thl) memory cells by contacting or administering a population of Thl cells with an agent that inhibits CD44 receptor expression or activation. The invention further provides a method of stimulating memory Thl cell survival comprising contacting or administering Thl cells with an agent that increases CD44 receptor activation or expression in the cells. The invention additionally provides a method of screening for agents capable of modulating Thl cell survival.