发明名称 |
PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF |
摘要 |
<p>Pyrazine derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein the designation of R1, R2, R3 and R4 are provided herein. Syntheses for preparation of such compounds are disclosed. Methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments are disclosed. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.</p> |
申请公布号 |
WO2012003784(A1) |
申请公布日期 |
2012.01.12 |
申请号 |
WO2011CN76756 |
申请日期 |
2011.07.01 |
申请人 |
JINAN UNIVERSITY;WANG, YUQIANG;SUN, YEWEI;YU, PEI;DU, JING;ZHANG, GAOXIAO |
发明人 |
WANG, YUQIANG;SUN, YEWEI;YU, PEI;DU, JING;ZHANG, GAOXIAO |
分类号 |
A61P3/00;C07D295/00;A61K31/495;A61P1/00;A61P5/00;A61P9/00;A61P11/00;A61P25/00;A61P27/00;A61P31/00;A61P35/00;C07D403/12 |
主分类号 |
A61P3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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