发明名称 |
PROGESTERONE RECEPTOR ANTAGONISTS |
摘要 |
Disclosed is a progesterone receptor antagonist compound of formula I, wherein: R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group. Specific compounds disclosed include: 11beta-[4-(1,2-dihydroxyethyl)phenyl]-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-one; and 20,20,21,21,21-pentafluoro-17-hydroxy-11beta-[4-(hydroxyacetyl)phenyl]-19-nor-17alpha-pregna-4,9-dien-3-one. Further disclosed is a pharmaceutical composition comprising a compound of formula I, and the use of the compound of formula I in the manufacture of a medicament for the treatment of endometriosis, myomas, hormone-dependent tumours, or for female contraception.
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申请公布号 |
NZ576927(A) |
申请公布日期 |
2012.01.12 |
申请号 |
NZ20070576927 |
申请日期 |
2007.11.14 |
申请人 |
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT |
发明人 |
FUHRMANN, ULRIKE;SCHMIDT, ANJA;CLEVE, ARWED;PETROV, ORLIN;GARKE, GUNNAR;PRUEHS, STEFAN;BRUDNY-KLOEPPEL, MARGARETE;ROTTMANN, ANTJE;HASSELMANN, RAINER;SCHULTZE-MOSGAU, MARCUS;MOELLER, CARSTEN |
分类号 |
A61K31/567;A61P5/36;C07J1/00;C07J21/00;C07J51/00 |
主分类号 |
A61K31/567 |
代理机构 |
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