Recombinant adenovirus target-oriented co-expressing human p53 and p53aip1

摘要

A recombinant adenovirus target-oriented co-expressing human p53 variant and p53AIP1 is disclosed, which is inserted an expression cassette co-expressing human p53 variant and p53AIP1 in E1 deletion region of the adenovirus. The expression cassette consists of tumor specific promoter, human p53 variant, internal ribosome entry site (IRES), human p53AIP1, and SV40.