Anti-TAT226 antibodies and immunoconjugates

摘要

Disclosed is a monoclonal antibody that binds to Tumor-associated Antigenic Target no. 226 (TAT226), wherein the antibody comprises (I) an HVR-H1 comprising the amino acid sequence of SEQ ID NO:4; (2) an HVR-H2 comprising the amino acid sequence of SEQ ID NO:5; (3) an HVR-H3 comprising an amino acid sequence that conforms to the consensus sequence of SEQ ID NO: 12; (4) an HVR-L1 comprising the amino acid sequence of SEQ ID NO:12; (5) an HVR-L2 comprising the amino acid sequence of SEQ ID NO:13; and (6) an HVR-L3 comprising an amino acid sequence that conforms to the consensus sequence of SEQ ID NO:19. Further disclosed is a monoclonal antibody that binds to TAT226 , wherein the antibody comprises a heavy chain variable domain having at least 95% sequence identity to an amino acid sequence selected from SEQ ID NO:21-25 and a light chain variable domain having at least 95% sequence identity to an amino acid sequence selected from SEQ ID NO:26-31, and wherein said antibody that binds TAT226 has a dissociation constant (KD) of <10 nM.