摘要 |
<p>Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.</p> |
申请人 |
ARDELYX, INC.;LEWIS, JASON, G.;JACOBS, JEFFREY, W.;REICH, NICHOLAS;LEADBETTER, MICHAEL, R.;BELL, NOAH;CHANG, HAN-TING;CHEN, TAO;NAVRE, MARC;CHARMOT, DOMINIQUE;CARRERAS, CHRISTOPHER;LABONTE, ERIC |
发明人 |
LEWIS, JASON, G.;JACOBS, JEFFREY, W.;REICH, NICHOLAS;LEADBETTER, MICHAEL, R.;BELL, NOAH;CHANG, HAN-TING;CHEN, TAO;NAVRE, MARC;CHARMOT, DOMINIQUE;CARRERAS, CHRISTOPHER;LABONTE, ERIC |