METHOD FOR MANUFACTURING OF QUINOLINE-3-CARBOXAMIDES
摘要
<p>A method for preparing a compound of formula (I) by reacting the appropriate alkyl ester and an aniline derivative, in a refluxing mixture containing an aliphatic solvent or a mixture of aliphatic solvents having a boiling point in the range of 68-191 °C; condensing vapors of the refluxing mixture; treating the condensed vapors with an alcohol scavenging agent or a mixture of alcohol scavenging agents; and returning the condensed vapors back to the reaction mixture.</p>
申请公布号
WO2012004338(A1)
申请公布日期
2012.01.12
申请号
WO2011EP61490
申请日期
2011.07.07
申请人
ACTIVE BIOTECH AB;BOCK, LILLEMOR MARIA;HOLMBERG, PAER HENNING;JANSSON, KARL-ERIK