发明名称 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION
摘要 The present invention relates to a compound of Formula (I): wherein: R1 is H, —NHCOOR1a, C5-6 cycloalkyl, or phenyl; where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R10; R1a is C1-3 alkyl which may be substituted with one to three of the same or different substituents selected from F and Cl; R2 is H, —COOH, —CH2 COOH, —COOR2a, or —CH2COOR2a; R2a is C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms; R3 is H, C1-6 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R11; R10 is F, Cl, CF3, or C1-2 alkyl; R11 is halogen atom, hydroxy, or cyano; W is selected from: W2a is H, halogen atom, cyano, C1-2 alkyl, or C3-5 cycloalkyl, or a pharmaceutically acceptable salt or ester thereof.
申请公布号 KR20120004467(A) 申请公布日期 2012.01.12
申请号 KR20117024895 申请日期 2010.03.15
申请人 MSD K.K.;VERTEX PHARMACEUTICALS INCORPORATED 发明人 BINCH HAYLEY;HASHIMOTO MASAYA;MORTIMORE MICHAEL;OHKUBO MITSURU;SUNAMI TOMOKO
分类号 C07D401/14;A61K31/506;A61P35/00;C07D401/04 主分类号 C07D401/14
代理机构 代理人
主权项
地址