| 发明名称 |
PROPANOIC ACID DERIVATIVE THAT INHIBITS THE BINDING OF INTEGRINS TO THEIR RECEPTORS |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for the inhibition of the binding of VCAM-1 (vascular cell adhesion molecule-1) and fibronectin in white blood cells. <P>SOLUTION: This invention relates to: a method for the inhibition of the binding of α<SB POS="POST">4</SB>β<SB POS="POST">1</SB>integrin to its receptors, for example VCAM-1 and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which α<SB POS="POST">4</SB>β<SB POS="POST">1</SB>is involved. <P>COPYRIGHT: (C)2012,JPO&INPIT |
| 申请公布号 |
JP2012006932(A) |
申请公布日期 |
2012.01.12 |
| 申请号 |
JP20110155493 |
申请日期 |
2011.07.14 |
| 申请人 |
ENCYSIVE PHARMACEUTICALS INC |
发明人 |
BIEDIGER RONALD J;HOLLAND GEORGE W;KASSIR JAMAL M;LI WEN;MARKET ROBERT V;SCOTT IAN L;WU CHENGDE |
| 分类号 |
C07D213/64;C07D229/00;A61K31/192;A61K31/33;A61K31/4166;A61K31/4178;A61K31/4184;A61K31/44;A61K31/4412;A61K31/443;A61K31/465;A61K31/497;A61K31/498;A61K31/501;A61K31/505;A61K31/517;A61P1/04;A61P3/10;A61P7/00;A61P9/10;A61P11/06;A61P17/00;A61P19/02;A61P25/00;A61P29/00;A61P35/00;A61P35/04;A61P37/06;A61P37/08;A61P43/00;C07D213/30;C07D215/02;C07D235/04;C07D239/36;C07D317/60;C07D405/12;C07D409/06;C07D409/14 |
主分类号 |
C07D213/64 |
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