发明名称 |
COMPOUND FOR USE IN PEPTIDE SYNTHESIS |
摘要 |
The present invention generally relates to processes and methods of peptide and protein synthesis. The present invention also relates to specific compounds for use in such processes and methods. It is shown herein that peptides with a C-terminal tertiary N,N-bis(2-mercaptoethyl)-amide (BMEA) undergo N-to-S acyl transfer at weakly acidic pH to form a transient thioester which can be captured for direct ligation with a cysteinyl peptide. These C-terminal BMEA peptides are easily prepared with standard Fmoc solid-phase synthesis protocols, thus giving a very convenient access to the thioester components for native chemical ligation. |
申请公布号 |
WO2012005691(A1) |
申请公布日期 |
2012.01.12 |
申请号 |
WO2011SG00236 |
申请日期 |
2011.07.06 |
申请人 |
NANYANG TECHNOLOGICAL UNIVERSITY;LIU, CHUAN FA |
发明人 |
LIU, CHUAN FA |
分类号 |
C07C323/60;C07K1/04;C07K1/06 |
主分类号 |
C07C323/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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