POSACONAZOLE INTRAVENOUS SOLUTION FORMULATIONS STABILIZED BY SUBSTITUTED BETA-CYCLODEXTRIN
摘要
The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified ß-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.
申请公布号
WO2012005973(A1)
申请公布日期
2012.01.12
申请号
WO2011US41715
申请日期
2011.06.24
申请人
SCHERING CORPORATION;HEIMBECHER, SUSAN, K.;MONTEITH, DAVID