NUCLEIC ACID DELIVERY COMPOSITION AND CARRIER COMPOSITION, PHARMACEUTICAL COMPOSITION USING THE SAME, AND METHOD FOR NUCLEIC ACID DELIVERY

摘要

Disclosed is an excellent composition for nucleic acid delivery, which is reduced in cytotoxicity and has high nucleic acid introduction efficiency and high gene expression efficiency. Specifically disclosed is a composition for nucleic acid delivery, which contains: a block copolymer that has a non-charged hydrophilic polymer segment and a cationic polymer segment; a cationic polymer; and a nucleic acid. The mole percentage (B/H ratio) of the cationic groups contained in the block copolymer relative to the total cationic groups contained in the block copolymer and the cationic polymer is 25-90%.