COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
摘要
A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
申请公布号
CA2803248(A1)
申请公布日期
2012.01.12
申请号
CA20112803248
申请日期
2011.06.28
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
GREEN, JEREMY;WILSON, DEAN M.;KONG, LAVAL CHAN CHUN;DAS, SANJOY KUMAR;POISSON, CARL;COURT, JOHN J.;TANG, QING;LI, PAN;COLLIER, PHILIP N.;WAAL, NATHAN;LAUFFER, DAVID J.;DORSCH, WARREN