发明名称 |
AGONIST ANTIBODY AGAINST PROTEIN TYROSINE KINASE SAL-S1 |
摘要 |
Agonist antibody is disclosed which binds to the extracellular domain of receptor protein tyrosine kinase pTK, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibody is useful for activating its respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed. |
申请公布号 |
PT2067790(E) |
申请公布日期 |
2012.01.11 |
申请号 |
PT20080021130T |
申请日期 |
1995.04.04 |
申请人 |
GENENTECH, INC. |
发明人 |
WILLIAM MATTHEWS;BRIAN D. BENNETT;DAVID GOEDDEL;JAMES M. LEE;SIAO PING TSAI;WILLIAM I. WOOD |
分类号 |
C12N15/09;C12N15/12;A61K38/00;A61K39/395;A61P43/00;C07H21/04;C07K7/08;C07K14/71;C07K14/82;C07K16/18;C07K16/28;C07K16/40;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/12;C12N15/02;C12N15/85;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;G01N33/566;G01N33/573 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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