Interfering RNA duplex having blunt-ends and 3'-modifications
摘要
<p>The present invention relates to double-stranded RNA compounds with at least one blunt end comprising at least one 3'-end modified to an hydroxypropylphosphodiester.
The RNA of the invention is useful as a medicament, for inhibiting expression of a target gene and for drug screening.</p>
申请公布号
EP2338995(A3)
申请公布日期
2012.01.11
申请号
EP20100184568
申请日期
2004.08.27
申请人
NOVARTIS AG;NOVARTIS PHARMA GMBH
发明人
WEILER, JAN;HALL, JONATHAN;BOLOGNA, JEAN-CHARLES;NATT, FRANCOIS JEAN-CHARLES;HAENER, ROBERT
