发明名称 |
NUCLEIC ACID COMPLEX AND NUCLEIC ACID-DELIVERING COMPOSITION |
摘要 |
<p>This invention relates to a nucleic acid complex with low toxicity and high safety that can maintain a nucleic acid molecule capable of RNA interference or translation inhibition, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid molecule capable of RNA interference or translation inhibition and a cycloamirose. Further, by using a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, efficiency of intracellular delivery, and persistence of the nucleic acid in the cell can be further improved.</p> |
申请公布号 |
EP2405001(A1) |
申请公布日期 |
2012.01.11 |
申请号 |
EP20100748819 |
申请日期 |
2010.03.04 |
申请人 |
TAKEUCHI, HIROFUMI;OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
TAKEUCHI, HIROFUMI;TOZUKA, YUICHI;MURATA, MITSUTAKA;TOYOBUKU, HIDEKAZU |
分类号 |
C12N15/113;A61K9/127;A61K31/7088;A61K31/713;A61K47/36 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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