发明名称 METHOD OF PRODUCING 3(R)-(2-HYDROXY-2,2-DITHIEN-2-YLACETOXY)-1-(3-PHENOXYPROPYL)-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE
摘要 FIELD: chemistry. ^ SUBSTANCE: described is a method of producing 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide by reacting 1-azabicyclo[2.2.2]oct-3(R)yl ether of 2-hydroxy-2,2-dithien-2-ylacetic acid and 3-phenoxypropyl bromide, where the reaction takes place in a solvent or mixtures of solvents, having boiling point ranging from 50 to 210C and selected from a group comprising ketones and cyclic ethers, preferably in acetone, dioxane and tetrahydrofuran. ^ EFFECT: efficient method of obtaining the compounds. ^ 12 cl, 8 ex, 1 tbl
申请公布号 RU2439070(C2) 申请公布日期 2012.01.10
申请号 RU20090105827 申请日期 2007.07.16
申请人 AL'MIRAL', S.A. 发明人 BUSKETS-BAKE NURIJA;PAKHUELO-LORENSO FRANSESKA
分类号 C07D453/02 主分类号 C07D453/02
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