DRUG STIMULATING PRODUCTION OF GRANULOCYTE-MACROPHAGE COLONY-FORMING FACTOR IN CELLS OF MONONUCLEAR PHAGOCYTE SYSTEM

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to medicine, particularly immunology, namely immunocorrection drugs, and can be used as an inducer of a granulocyte-macrophage colony-forming factor in cells of a mononuclear phagocyte system in vitro and for efferent therapy in pathological conditions accompanied by decrease in cell-mediated immunity. The drug represents oxidised dextrane of average molecular weight 35 - 65 kDa. The drug can be presented in the form of a solution or a nanoliposomal emulsion of the concentration of oxidised dextrane 1-5 wt %. The drug is applied by introduction in a cell culture of the mononuclear phagocyte system in an amount containing oxidised dextrane 125-250 mcg per culture medium 1 ml. ^ EFFECT: drug under the invention exhibits high biocompatibility. ^ 8 cl, 1 tbl, 4 ex