COMPOSITIONS OF INTERFERON-BETA STABILIZED WITH HIGHLY PURIFIED MANNITOL

摘要

Stabilized pharmaceutical formulations comprising IFN-.beta. and highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-.beta. adducts in comparison with IFN-.beta. formulated with mannitol that has not been highly purified. Methods for increasing the stability of IFN-.beta. or a variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.