发明名称 |
A NEW METHOD OF USING N-THIO COMPOUNDS FOR OLIGONUCLEOTIDE SYNTHESIS |
摘要 |
A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R1 and R2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.
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申请公布号 |
CA2805546(A1) |
申请公布日期 |
2012.01.05 |
申请号 |
CA20112805546 |
申请日期 |
2011.06.30 |
申请人 |
GIRINDUS AMERICA, INC. |
发明人 |
HE, YIGANG;SOROKIN, VICTOR;MAZUR, WIESLAW ADAM |
分类号 |
C07H1/00;C07H21/00 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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