发明名称 |
METHOD FOR CONTROLLED RELEASE OF AN ACID-UNSTABLE PHYSIOLOGICALLY ACTIVE SUBSTANCE |
摘要 |
It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax. |
申请公布号 |
US2012003311(A9) |
申请公布日期 |
2012.01.05 |
申请号 |
US20060543991 |
申请日期 |
2006.10.06 |
申请人 |
YOSHITAKE TAKASHI;MIZUNO MITSURU;MOROSHIMA KENJI;AOKI SHIGERU;EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
YOSHITAKE TAKASHI;MIZUNO MITSURU;MOROSHIMA KENJI;AOKI SHIGERU |
分类号 |
A61K9/26;A61K9/14;A61K9/28;A61K9/36;A61K9/62;A61K31/4439;A61K47/06;A61K47/10;A61K47/12;A61K47/14;A61K47/32;A61K47/38;A61P1/04;C07D401/12 |
主分类号 |
A61K9/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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