| 发明名称 |
METHOD FOR PREPARING A SITE-SPECIFIC PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE |
| 摘要 |
The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life. |
| 申请公布号 |
US2012003712(A1) |
申请公布日期 |
2012.01.05 |
| 申请号 |
US201013255199 |
申请日期 |
2010.03.18 |
| 申请人 |
SONG DAE HAE;SHIN JAE HEE;LEE JAE MIN;PARK YOUNG KYUNG;KWON SE CHANG;LEE GWAN SUN;HANMI HOLDINGS CO., LTD. |
发明人 |
SONG DAE HAE;SHIN JAE HEE;LEE JAE MIN;PARK YOUNG KYUNG;KWON SE CHANG;LEE GWAN SUN |
| 分类号 |
C12N9/00;C07K7/04;C07K7/16;C07K9/00;C07K14/475;C07K14/505;C07K14/52;C07K14/53;C07K14/575;C07K14/585;C07K14/59;C07K14/595;C07K14/605;C07K14/61;C07K14/62;C07K14/655 |
主分类号 |
C12N9/00 |
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