| 摘要 |
The present invention relates to a temperature-sensitive bioactive material carrier and to a method for preparing same. More particularly, the present invention relates to a temperature-sensitive bioactive material carrier and to a method for preparing same, wherein the carrier comprises a biodegradable amphiphilic block copolymer, wherein said coplymer comprises polysaccharides or both polysaccharides and succinic anhydrides as a hydrophilic block, and polylactides as a nonionic block. The hydrophilic polymer/polylactide copolymer according to the present invention forms stable composites in in-vivo conditions through ionic bonding or temperature-sensitive hydrophobic bonding to bioactive materials such as proteins, polynucléotides, or the like, thus enabling the easy in vivo delivery of bioactive material, and therefore can be used as an in vivo drug delivery system. |
