发明名称 |
VACCINE AGAINST BOTULISM |
摘要 |
The invention relates to novel DNA and protein vaccines against Clostridium botulinum. The DNA vaccine includes a DNA molecule that includes a first segment encoding a fragment of a heavy chain region of a Clostridium botulinum neurotoxin, wherein the first segment is codon-enhanced to improve expression of the isolated DNA molecule in a mammalian host, and preferably a second segment that encodes a secretion signal peptide. The chimeric protein of the present invention includes the secretion signal peptide linked N-terminal of the fragment of a heavy chain region of a Clostridium botulinum neurotoxin. Use of these materials to raise antibodies, and to impart resistance against Clostridium botulinum to a mammal is also disclosed.
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申请公布号 |
US2012003241(A1) |
申请公布日期 |
2012.01.05 |
申请号 |
US20080672604 |
申请日期 |
2008.08.08 |
申请人 |
ZENG MINGTAO;PICHICHERO MICHAEL E.;XU QINGFU;UNIVERSITY OF ROCHESTER |
发明人 |
ZENG MINGTAO;PICHICHERO MICHAEL E.;XU QINGFU |
分类号 |
A61K39/395;A61K39/08;A61P31/04;A61P37/04;C07K16/12;C07K19/00;C12N5/10;C12N15/31;C12N15/62;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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