发明名称 |
NOVEL SHRNA GENE THERAPY FOR TREATMENT OF ISCHEMIC HEART DISEASE |
摘要 |
Short hairpin RNA (shRNA) interference therapy targeting hypoxia inducible factor—lot (HIF-1α) prolyl-4-hydroxylase protein (HIF-PHD2) is used for treatment of myocardial ischemia. This treatment can be followed noninvasively by molecular imaging. Provided are compositions comprising novel vectors encoding shRNA targeting the HIF-1αand asparaginyl hydroxylase genes. The vectors encoding shRNA are also useful for the treatment of cardiac diseases, peripheral vascular diseases and decubitis ulcers.
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申请公布号 |
US2012004283(A1) |
申请公布日期 |
2012.01.05 |
申请号 |
US20090998075 |
申请日期 |
2009.09.15 |
申请人 |
WU JOSEPH C.;GIACCIA AMATO JOHN;HUANG MEI;CHAN DENISE A.;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO |
发明人 |
WU JOSEPH C.;GIACCIA AMATO JOHN;HUANG MEI;CHAN DENISE A. |
分类号 |
A61K31/7105;A61P7/00;A61P9/10;A61P17/02;C12N15/85 |
主分类号 |
A61K31/7105 |
代理机构 |
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