| 摘要 |
<p>A GWAS is carried out using a large sample pool from Japanese patients, and novel single nucleotide polymorphisms (SNPs) that are located in regions other than an HLA region and have a significant (P < 0.05) relationship with BD are successfully identified. Among the SNPs, specific SNPs which have a particularly strong relationship with BD are subjected to fine mapping in a peripheral region and linkage disequilibrium structure analysis. As a result, multiple SNPs which exhibit a strong relationship with BD in the inside and outside of a linkage disequilibrium block to which the SNPs identified in the GWAS belong are found. By employing these polymorphisms as measures, it becomes possible to determine the risk of BD with high reliability.</p> |
