发明名称 |
NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF |
摘要 |
Provided are compounds having excellent Syk-inhibitory activity and pharmaceutical compositions. Specifically provided are: nicotinamide derivatives represented by general formula (I) or salts thereof; and pharmaceutical compositions for the treatment of Syk-related diseases, which contain the nicotinamide derivatives or the salts thereof. In general formula (I), R1 is a halogen atom; R2 is C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-8 cycloalkyl, aryl, aralkyl (wherein the alkyl moiety has 1 to 6 carbon atoms), or a heterocyclic group, each being optionally substituted; R3 is aryl or a heterocyclic group, each being optionally substituted; R4 and R5 are each a hydrogen atom or the like; and R2 and R4 together with the nitrogen atom to which R2 and R4 are bonded may form an optionally substituted cyclic amino group. |
申请公布号 |
CA2803842(A1) |
申请公布日期 |
2012.01.05 |
申请号 |
CA20112803842 |
申请日期 |
2011.06.30 |
申请人 |
FUJIFILM CORPORATION |
发明人 |
FUJIWARA, HIDEYASU;SATO, KIMIHIKO;MIZUMOTO, SHINSUKE;SATO, YUICHIRO;KURIHARA, HIDEKI;KUBO, YOHEI;NAKATA, HIYOKU;BABA, YASUTAKA;TAMURA, TAKASHI;KUNIYOSHI, HIDENOBU;HAGIWARA, SHINJI;YAMAMOTO, MARI |
分类号 |
C07D213/82;A61K31/44;A61K31/443;A61K31/4439;A61K31/444;A61K31/4545;A61K31/4709;A61K31/496;A61K31/498;A61K31/4985;A61K31/506;A61K31/517;A61K31/5377;A61K31/5383;A61P7/00;A61P29/00;A61P37/00;A61P43/00;C07D215/40;C07D401/04;C07D401/12;C07D401/14;C07D405/14;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D471/04;C07D491/048;C07D491/056;C07D491/107;C07D498/04;C07D513/04 |
主分类号 |
C07D213/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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