发明名称 IMMUNOSTIMULATORY INOSINE MONOPHOSPHATE 5'-NUCLEOTIDASE RESISTANT DERIVATIVE, AND ITS USE
摘要 <P>PROBLEM TO BE SOLVED: To provide an inosine-5'-monophosphate derivative which has higher immunostimulatory capacity, is more stable and has resistance to 5'-nucleotidase. <P>SOLUTION: Regarding the method for producing inosine-5'-monophosphate or its derivative having resistance to 5'-nucleotidase, the method chemically denaturalizes inosine-5'-monophosphate to a compound expressed by formula (I) and holds the biological activity of the inosine-5'-monophosphate in the living body (In the formula, R is selected from a group composed of alkyl, alkoxy and the second amino compound.). <P>COPYRIGHT: (C)2012,JPO&INPIT
申请公布号 JP2012001552(A) 申请公布日期 2012.01.05
申请号 JP20110177779 申请日期 2011.08.15
申请人 UNIV OF SOUTH FLORIDA 发明人 HADDEN JOHN W;GINER SOROLLA ALFREDO;MASIHI NOEL K
分类号 A61K31/7076;A61K31/01;A61K39/00;A61K39/112;A61K39/29;A61K39/39;A61P31/10;A61P31/12;A61P31/16;A61P31/18;A61P35/00;A61P37/04;A61P43/00 主分类号 A61K31/7076
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